Broccoli May Help Prevent Prostate Cancer – Study

Multiple studies have assessed the impact of broccoli on human health, with most of them revealing a host of health benefits associated with this green veggie. Now much evidence has come to light revealing the nutritional and medicinal benefits of broccoli; it can help prevent prostate cancer!

Sometimes referred to as the “super veggie,” broccoli is an excellent source of a wide variety of vitamins and nutrients that are important for good health.

Research in the past has has claimed that sulforaphane – a sulfur-containing compound naturally found in broccoli and other cruciferous vegetables – can help to prevent cancer or slow the growth of cancer cells. This compound helps in the production of enzymes that combat cancer-causing substances in the body.

The new study adds to this growing evidence, showing how broccoli can help prevent prostate cancer.
Given that the cruciferous vegetables are high in sulforaphanes, men should increase their intake of such vegetables including broccoli to lower their risk of developing prostate cancer, suggest researchers in Oregon State University (OSU) in the US.

In their study, the OSU researchers found that sulforaphane slashed the expression of long noncoding RNAs (lncRNAs) in prostate cancer cells, which inhibited the malignant cells’ ability to form colonies.

“It’s obviously of interest that this dietary compound, found at some of its highest levels in broccoli, can affect lncRNAs,” says principal investigator Emily Ho, of the Moore Family Center for Whole Grain Foods, Nutrition and Preventive Health at OSU.

“This could open the door to a whole range of new dietary strategies, foods, or drugs that might play a role in cancer suppression or therapeutic control,” she adds.

An lncRNA gene, called LINC01116, augments in number in a human cell line of prostate cancer, but can be reduced by treatment with sulforaphane, Ho and her colleagues affirmed.

“The study showed that treatment with sulforaphane could normalise the levels of this lncRNA,” said lead study author Laura Beaver, Research Associate at Oregon State University in the US.

Beaver and colleagues said that their results may have important implications not only for cancer prevention, but also for cancer treatment.

“It would be of significant value if we could develop methods to greatly slow the progress of cancer, [and] help keep it from becoming invasive,” Beaver said, adding that their work “reinforces the idea that lncRNAs are an exciting new avenue for chemoprevention research, and chemicals derived from diet can alter their expression.”

Beaver and her colleagues reported their results recently in The Journal of Nutritional Biochemistry.